so how would you address the science?
I don't, because at their core, science and religion do not overlap with each other.
Again, science is based on the principal of methodological naturalism, which is the presumption for methodological purposes that the natural world is all there is. It therefore limits any and all scientific explanations to natural causes. Religion is based on belief in the supernatural which science does not address.
You talked about thermodynamics and entropy, that's about energy transfer and temperatures which have no application outside of space and time. Many skeptics talk about quantum physics, but that doesn't apply here either because we can only examine it within the boundaries of space. It's said that virtual particles pop in and out of existence from nothing but this is an argument from ignorance fallacy, just because we don't know where they come from doesn't mean they come from nothing.
We are physical beings constrained within a physical universe, there is no form of experimentation we could possibly conduct that goes beyond the physical.
all you are doing, is reverting to philosophy when confronted with the science....
Because there's nothing left. If science doesn't address religious claims (because it does not have access to them) then all we can do is figure out what to do about this limitation and how it relates to what we should believe. That is necessarily a matter of philosophy.