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@secularmerlin
Surely the point is there is no difference from a physics point of view.... so where does the difference originate? One can alays deny there is a difference, but that strikes me as feigning blindnstress to avoid addressing a tricky question beause there is something intrisically different about breaking a manequin and killing a person.
my partial solution is to think of 'reality' as consisting of the physical and the mental. Traditionally, science has always concerned itself with only the physical (ie u1). The result is that we are pretty good at explaining the physical world, but pretty awful at at explaining the mental. We have good theories for quarks and supernova, no theories at all for qualia. As humans, love and duty are as much causes forces as are gravity and magnetism (perhaps even more so), but traditional science has steered well clear of them!
The focus on physicalism has served us very well - its given us the modern world. But it fails in acoulpe of ways. One is that science gives no insight into moral issues. Science is - by design -amoral. That is not a defect of science; science is (in my vocaulary) the study of u1. If there was no consciousness in the universe, science would tell you all there was to know about it. But in a universe with consciousness (u2, our universe) it does not tell us 'what is a good life'?.
The reason I introduced the notion of u2 is to illuminate the difference between a universe with and a universe without consciousness. Because consciousness exists, desciptions in terms of u1 only describe only part of reality.
Theists are right about one thing - a purely physical universe has no meaning or purpose. They are wrong to think the solution is the eistence of a god. The reason the universe gained meaning and purpose is that matter self-organised into structures that manifest consciousness - ie sentient brains. If no brain existed, things would still happen, but nothing would matter, nothing would be good or bad.
But consciousness DOES exist. I think that is why one-eyed physicalism can appear empty of meaning and nihilistic.
A longer, more coherent exposition of my ideas will have to wait until I write my book!