1) It will make people more isolated. Work is where many people meet mutual friends, and in even some cases, their dating partners. We've already seen what this looks like during the 2020 lockdowns where social media has replaced real human interaction. But even now, I notice there are far less people in Meetup groups in 2022 than in 2019, despite covid being mitigated; people have just adapted to the new lifestyle. In short-term, people will find remote work more liberating, but in the long run, will it increase depression and social anxiety? Will this cause people to be more sedentary?
You could argue that people can just work at home, but then still go to the gym and go out to a social event at night, and with no commute time, they'd have more free time to do that. But realistically, will this actually pan out that way? Or will people just choose the path of least resistance?
^ This point is relatively subjective. And some people may prefer to be homebodies. But the 2nd point is more concrete.
2) Foreign competition. If work is all remote, why would IT, cybersecurity and data analysts pay an American or European $30 an hour, when they could pay someone in India $10-15 an hour? Granted, competition would help developing countries but would hurt developed countries.